This document presents the summary results of the Ocean Decade Tropical Americas and Caribbean Regional Kick-off Conference convened by IOC of UNESCO Sub-Commission for the Caribbean and Adjacent Regions-IOCARIBE with UN Agencies and Partners under the auspices of the governments of Barbados and Colombia virtual session held December 16-17, 2021. The Regional Kick-off Conference marked the launch of the UN Ocean Decade in the Tropical Americas and  the Caribbean Region (TAC).  The Conference highlighted emerging regional engagement in co-designing partnerships for Regional Ocean Decade Actions and invited the mobilization of contributions and expressions of interest by UN and regional agencies, governments, industry and private sectors, and other stakeholder groups. It aimed to catalyze partnerships among various ocean stakeholder communities in the region. It reinforced the co-design of transformative ocean science solutions to the Ocean Decade Challenges to achieve the Ocean Decade Outcomes and Sustainable Development Goals.